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Voted NewBeauty's Favorite Serum for Sensitive Skin, 2026 — Shop now →

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Peptide

Peptides

Also known as Palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, acetyl tetrapeptide-5

Short chains of amino acids that act as messengers in the skin. They help skin look firmer and smoother, and some target specific concerns like under-eye puffiness.

What are peptides?

Peptides are short chains of amino acids, the same building blocks that make up proteins like collagen. In skincare, specific peptides are chosen because they act like messengers, sending signals that help skin look smoother and firmer. Different peptides do different jobs, which is why you will often see more than one in a formula.

What they do for your skin

  • Help skin look firmer and more supported
  • Soften the look of fine lines and wrinkles
  • Reduce the look of puffiness and dark circles under the eyes
  • Support a smoother, more even skin surface

The peptides in Revoderm formulas

Our Hydrating Toner pairs palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, a duo often used for firmness and a calmer-looking complexion. EyeLyte Retinol Anti-Aging Eye Cream uses acetyl tetrapeptide-5 to target under-eye puffiness alongside retinol. Our Detox Facial Cleanser contains acetyl octapeptide-3, which has its own entry in the library.

How to use them

Peptides work best in products that stay on the skin, like toners, serums, eye creams and moisturizers. They are gentle enough to use morning and night and layer easily with retinol, hyaluronic acid and niacinamide. Consistency matters more than strength, so use them daily and give them a couple of months.

Who they're for

Anyone noticing early signs of aging, and anyone who wants anti-aging benefits without the irritation that can come with stronger actives. They are a good option for sensitive skin.

Common questions

Can I use peptides with retinol?
Yes. They work well together, and peptides are gentle enough that they will not add to retinol irritation.
Can I use peptides with vitamin C?
Yes. Most people can use both. If you are sensitive, use vitamin C in the morning and peptides at night.
How long do peptides take to work?
Expect gradual results. Most people notice a difference in how their skin looks after 8 to 12 weeks of daily use.
Are peptides safe for sensitive skin?
Yes. Peptides are among the best-tolerated anti-aging ingredients.

This guide is general skincare information, not medical advice. If you're pregnant, nursing, using prescription skincare or have a skin condition, check with your doctor or our clinic team first.

Not sure what your skin needs?

Take our skin quiz for a routine matched to your skin, or book a free consult with our skin experts.